WG C: Exposure & Hazard Assessment

Chair: Wouter Fransman, TNO (wouter.fransman@tno.nl)

Co-chairs: Claus Svendsen (NERC-CEH), Soco Vazquez (LEITAT), Wim de Jong (RIVM), Vicki Stone (HWU), Tommaso Serchi (LIST)

Background

This working group originates from two working groups on Exposure assessment (WG3 in the old structure) and Hazard identification (WG2 in the old structure) and covers a large number of topics related to exposure and hazard assessment of nanomaterials. Both these previous WGs were subdivided into topics on human (exposure and hazard/toxicology) and environment (environmental fate/exposure and ecotoxicology). Furthermore, this WG is closely linked with the new WG D on ‘Models and tools for risk assessment’.

We envisage a new Working Group that combines knowledge from four groups of experts, i.e.:

1. human exposure

2. human hazard

3. environmental exposure/release/fate

4. ecotoxicology

This will result in the creation of various teams, each with their own webpages, members, and collaborations. We would like to keep as much as possible the ongoing initiatives from the old WGs 2 and 3 and build from that basis to further extend the exchange of knowledge across projects, institutes and countries.

Analytical WG Structure

Sub-group on Human Exposure - Wouter Fransman (CaLIBRAte, NanoReg2, FutureNanoNeeds, EC4SafeNano, NanoSTREEM, NanoFase)

Sub-group on Release - Soco Vazquez (NanoFASE, CaLIBRAte)

Sub-group on Environmental Fate & Exposure - Claus Svendsen (NanoFASE, CaLIBRAte)

Sub-group on Human Hazard - Vicki Stone (GRACIOUS), Wim de Jong (PATROLS, CALIBRATE)

Sub-group on Ecotoxicology - Teresa Fernandes

Aims and objectives

• To encourage sharing of project methods, techniques/results/data by coordination and sharing through various means and activities. Information exchange of methods available within the Cluster. Validation of appropriate testing methods including identification of limitations.

• To encourage cross project technical best practice to extract, prepare and analyse samples, to characterise and quantify NM exposure properties in real product lifecycle, exposure and environmental samples.

• To encourage sharing of project results/data by coordination of transfer and hosting of libraries/(databases). Provision of results and outcome to the database (cooperation Working Group F ‘Data management’).

• Comparison in-vitro versus in-vivo results

• Description of correlation between biological effects and material properties (cooperation Working Group B ‘Materials and Standards’)

• Description of correlation between biological effects and exposure aspects and LCA.

• Dissemination of results (cooperation Working Group A ‘Training and education’).

Prospective coordination actions

• Harmonization of data collection, analysis, reporting, and formats for storage and retrieval.

• Development and agreement on research priorities

• Coordination and resulting tuning of running/planned projects activities between projects in the area of exposure assessment; subdivision of work etc.