NanoInformaTIX develops a web-based Sustainable Nanoinformatics Framework (SNF) platform for risk management of engineered nanomaterials (ENM) in industrial manufacturing. The tool will be based on the significant amounts of data on physico-chemical and toxicological and ecotoxicological properties of ENM generated over the last decades, as well as new data coming from research.
The final aim is to provide efficient user-friendly interfaces to enhance accessibility and usability of the nanoinformatics models to industry, regulators, and civil society, thus supporting sustainable manufacturing of ENM-based products
A database will be implemented by collecting and managing data from completed and ongoing projects;
- To provide multiscale bottom-up methods for ENM design and model advanced descriptors, implement a ‘Safe-by-Design’ approach;
- To develop models of ENM release and exposure, fate and environmental distribution, and bio-distribution;
- Top-down data mining and quantitative methods, to derive models of the ENM dose-response relationship for (eco)-toxicity, will allow ENM descriptors to be linked to adverse outcomes;
- Chain data sources and models will enable specific operations needed for risk assessment as well as predictions of properties and effects for safer design of quality products;
To improve model prediction using advanced descriptors; validate models by comparing model predictions with data from EU and national projects.
The online NanoInformaTIX SNF platform aims to help shortening the path from lab bench to the market, by providing:
- a global hub for ENM safe-by-design,
- a portal for manufacturers and scientists , for information on materials.
It will be based on predictive toxicology knowledge, thus enabling sustainable production of engineered nanomaterials (ENM) through:
- Reduction of animal experimentation
- Grouping/classifying ENM for risk assessment
The project will have important impact on:
- Regulators: sound, validated methodologies
- Industry: anticipate uncertainties and risks early in the innovation process
- Consumers: safer and better products on the market, transparency and trust
- Researchers: availability of tools to turn research into successful products
1 January 2019 – 28 February 2023
- Project Coordinator: Miguel A. Bañares – Consejo Superior de Investigaciones Científicas CSIC
- Project website: http://www.nanoinformatix.eu/
- E-mail: Lisa Bregoli – Warrant Hub SpA