All day
May 4, 2016 – May 5, 2016
n vitro high throughput screening platforms based on mechanistic injury pathways are been used for hazard assessment of nanomaterials (NM). Toxicity screening and other in vitro nanotoxicology assessment efforts in essence compare and rank nanomaterials relative to each other. It has been shown that that this ranking of NM is susceptible to dispersion and dosimetry protocols and partico-kinetics taking place in the in-vitro system, which continue to be poorly standardized. In addition, and this applies both to in vitro studies with submerged cell cultures as well as inhalation studies in rodents, extrapolation to human becomes more reliable when dose and dose rate at the site of depositions is determined accurately.
Mixed experimental/computational approaches to cellular dosimetry can be used by nanoparticle toxicologists to accurately calculate the delivered to cell dose metrics for various NMs and in vitro conditions as a function of exposure time. In addition, in vivo dosimetry models will allow researchers to estimate the delivered dose in any region of the respiratory system and to study the implications of particle properties and lung function parameters. More importantly, it enables nanoparticle toxicologists to bring to the same level in-vitro and in-vivo doses and help in the development of validated in-vitro cellular screening assays.
The objective of the workshop is to promote the use of emerging particle dosimetry approaches for (inhaled) nanomaterial in-vitro and in-vivo toxicological assessment. The workshop will include lectures, demonstration activities and exercises. Presenters are ready to interact with the participants so be prepared for some challenges.