Harmonised methods/requirements for biokinetic investigation
It is critically important to first understand the biokinetic behaviour. This information then needs to be applied in hazard screening is to understand where and when nanomaterials will interact with the biological system and the subsequent clearance and retention (rates). Information will be exchanged and unified among groups that have a focus on biokinetics to allow inter study comparisons. A list of research groups that perform biokinetic studies including the contact person and a short description of the experimental design and studies nanomaterials will be compiled. The review will include studies that focus on the major routes of nanomaterial uptake, studies of the rates and states of membrane interactions, studies of the bulk accumulation of materials, detailed studies of the passage of materials across membrane.
To understand the fate of internalised nanomaterials, a review of the status of current physiologically based pharmacokinetic ecember approaches applied in toxicology and the example (and potential) for the application to ecemberologie will be conducted. This review will include
- Use of biomembrane models to assess the interaction of engineered nanomaterials with biomembranes and the effect of the interaction on the structure, organisation and permeability of the models and the kinetics thereof. The interaction of nanomaterials with biomembranes is the first key process in any conceptual model of toxicokinetics.
- An assessment of the role of basic compartment model (one compartment and multi compartments) for describing the bulk uptake of relevant materials.
- Application of detailed physiologically based based models based on relevant physiological parameters.
- Use of combination models that incorporate both toxicokinetic and toxicodynamic aspects to understand the biokinetics of material, their mode of toxic action and the resulting effects on relevant biological parameters.
Time line : ecember 2012
Coordinated by : Dave Spurgeon
The composition of the Task Group is as follows and consists of the following members actively working in this area: