EU NanoSafety Cluster

Hazard WG

The working group

Chair: Flemming R. Cassee, RIVM, The Netherlands. NanoMile, NanoReg, NanoImpactnet (deputy- coordinator) and ENPRA (member) 

Co-chair: Teresa Fernandez, Heriot Watt University, Edinburgh, UK

 

 Download recent progress overview as presented on 26 Feb 2012 in Prague during the NSC meeting

What we wish to do

• Information exchange of methods available within the Cluster
• Harmonised methods/requirements for kinetic investigation
• Harmonised methods/requirements for appropriate toxicological endpoints
• Harmonised methods/requirements for appropriate in vitro tests (e.g. cell lines)
• Harmonised protocols for testing if appropriate
• Comparison in-vitro versus in-vivo results
• Validation of appropriate testing methods including identification of limitations
• Requirements for screening tests
• Description of correlation between biological effects and material properties (cooperation Working Group 1)
• Description of correlation between bioavailability/bioaccumulation/ADME and NP properties (cooperation Working Group 1)
• Description of correlation between biological effects and exposure aspects and LCA (cooperation Working Group 3)
• Provision of results and outcome to the database (cooperation Working Group 4)

 

 

Focus groups and tasks

This working group covers a large number of topics. This has lead and will result in the creation of various teams, each with their own webpages and members (see menu)

• Information exchange of methods available within the Cluster
• Harmonised methods/requirements for biokinetic investigation
• Create summaries of key results for further use by the dissemination group (cooperation Working Group 7)
• Immunosafety focus group
• Marine Ecotox focus group
• Biomembrane Nanosafety focus group
• Genotoxicity Focus group

 

Task	Who	When
Set up a online submission system to faciliate rapid and easy exchange of information	Flemming withNSCwebsite manager	Dec 2012
Workshop significance of biomembranes in nanotoxicology	Andrew Nelson	March 2012
Report risk-oriented ecotoxicological study in the marine environment	Ilaria Corsi	December 2012
Workshop on Nano-immunosafety within the International Congress of Immunology in 2013 in Rome	Diana Boraschi	2013
Dissemination of results (reports)	Teresa Fernandeze with WG7 members	December 2012
Review of the status of current physiologically based pharmacokinetic modeling approaches applied in toxicology a	Dave Spurgeon	December 2012
Contributions to Nanosafety:Strategic  Research Agenda towards Safe and  Sustainable Nanomaterial and  Nanotechnology Innovations	Flemming Cassee, Teresa Fernandes an others	Until May 2013
Symposium on Safety issues and regulatory challenges of nanomaterials	Socorro Vázquez-Campos (NANOPOlYTOX), Sergio Moya (HINAMOX), Maria Blázquez (NEPHH), Lang Tran (ENPRA) and Juan Riego Sintes (JRC)	May 2012

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