Hazard WG
The working group
Chair: Flemming R. Cassee, RIVM, The Netherlands. NanoImpactnet (deputy- coordinator) and ENPRA (member) 
Co-chair: Teresa Fernandez, Heriot Watt University, Edinburgh, UK 
What we wil do
- Information exchange of methods available within the Cluster
- Harmonised methods/requirements for kinetic investigation
- Harmonised methods/requirements for appropriate toxicological endpoints
- Harmonised methods/requirements for appropriate in vitro tests (e.g. cell lines)
- Harmonised protocols for testing if appropriate
- Comparison in-vitro versus in-vivo results
- Validation of appropriate testing methods including identification of limitations
- Requirements for screening tests
- Description of correlation between biological effects and material properties (cooperation Working Group 1)
- Description of correlation between bioavailability/bioaccumulation/ADME and NP properties (cooperation Working Group 1)
- Description of correlation between biological effects and exposure aspects and LCA (cooperation Working Group 3)
- Provision of results and outcome to the database (cooperation Working Group 4)
Focus groups and tasks
This working group covers a large number of topics. This has lead and will result in the creation of various teams, each with their own webpages and members (see menu)
- Information exchange of methods available within the Cluster
- Harmonised methods/requirements for biokinetic investigation
- Create summaries of key results for further use by the dissemination group (cooperation Working Group 7)
- Immunosafety focus group
- Marine Ecotox focus group
- Biomembrane Nanosafety focus group
- Genotoxicity Focus group
|
Task |
Who |
When |
|
Set up a online submission system to faciliate rapid and easy exchange of information |
Flemming withNSCwebsite manager |
June 2012 |
|
Workshop significance of biomembranes in nanotoxicology |
Andrew Nelson |
March 2012 |
|
Report risk-oriented ecotoxicological study in the marine environment |
Ilaria Corsi |
December 2012 |
|
Workshop on Nano-immunosafety within the International Congress of Immunology in 2013 inRome |
Diana Boraschi |
2013 |
|
Dissemination of results (reports) |
Teresa Fernandeze with WG7 members |
June & december 2012 |
|
Review of the status of current physiologically based pharmacokinetic modeling approaches applied in toxicology a |
Dave Spurgeon |
December 2012 |
|
Symposium on Safety issues and regulatory challenges of nanomaterials |
Socorro Vázquez-Campos (NANOPOlYTOX), Sergio Moya (HINAMOX), Maria Blázquez (NEPHH), Lang Tran (ENPRA) and Juan Riego Sintes (JRC) |
May 2012 |